Schizophrenia has been called “the worst disease affecting mankind” (1). It is a complex neuropsychiatric disorder, with multiple clinical features. These include cognitive impairment and deficits, mood symptoms, and psychiatric symptoms (hallucinations and delusions). It is also arguably the diagnosis that carries the greatest degree of stigma.

For many years, schizophrenia was untreatable, until the discovery of antipsychotic medications in the 1950s. These first-generation antipsychotic medications offered hope, but many people were left with either a lack of efficacy or intolerable side effects. Today, thanks to the newer second-generation antipsychotic medications, and clozapine for treatment-resistance, the odds for recovery from schizophrenia are possible for many.

The absence of insight is one of the most serious symptoms that prevents an individual with schizophrenia from receiving treatment. A lack of insight is called anosognosia. It is common in schizophrenia and other serious mental illness. It is more than denial, it is a firm and false belief that the affected individual is not sick and does not need medical treatment. Many people with schizophrenia develop delusions and believe things a mentally healthy person would find absurd. In the movie, A Beautiful Mind, while struggling with schizophrenia, Nobel Prize-winning mathematician John Nash believes that a microchip has been inserted in his body by the FBI because he is on a special mission.

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Psychology Today
January 27, 2024